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近年来由于生物药剂学的发展,人们已了解固体药物制剂的溶出特性对药物生物利用度的关系。片剂的溶出度研究在国内外已进行了大量的工作,而对其他非口服固体制剂的研究则较少。例如药物从栓剂中的释放,虽有若干报道,但重现性较差,不很成熟。它们可以归纳为几种方法:琼脂扩散法~[1]、搅拌法~[2～4]、转篮法~[5、6]、循环法~[7-9]和透析法~[10～12]。
In recent years due to the development of biopharmaceuticals, people have understood the relationship between the dissolution characteristics of solid pharmaceutical preparations and the bioavailability of the drug. Much work has been done on tablet dissolution studies at home and abroad, but less on other non-oral solid preparations. For example, the release of drugs from suppositories, although a number of reports, but poor reproducibility, not very mature. They can be summarized in several ways: Agar diffusion method [1], agitation method [2-4], spin basket method [5,6], circulation method [7-9] and dialysis method [ 12].