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通过研究发现糖皮质激素的分泌具有恒定的昼夜节律性,即午夜后分泌开始增加至清晨6～9时最高,继之分泌减少,到次日午夜降至最低,以往每日3～4次给药法违反时间规律,使糖皮质激素分泌的昼夜节律紊乱。现发现无论氢化可的松、强的松、地塞米松等,如果当体内血浆中自身皮质激素在高峰浓度时(即早晨7～8时)一次给药,对脑下垂体ACTH的释
Through the study found that the secretion of glucocorticoid has a constant circadian rhythms, that is, after midnight secretion began to increase to 6 to 9 am the highest, followed by a decrease in secretion to midnight the next day to a minimum, the previous daily 3 to 4 times to Drug law violates the law of time, so that glucocorticoid secretion circadian rhythm disorders. It has been found that regardless of hydrocortisone, prednisone, dexamethasone, etc., if the body when the plasma corticosteroids in a peak concentration (ie 7-8 o’clock in the morning) once administered to the release of pituitary ACTH