【摘 要】
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INTRODUCTION T lineage specific activation antigen 1 (TLiSA1), first reported by Burns in 1985[1], was renamed PTA1 in 1989 because of its expression on platele
【机 构】
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Department of Hepatobiliary Surgery, Xijing HospitalDepartment of Immunology, Faculty of Preclinical
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INTRODUCTION T lineage specific activation antigen 1 (TLiSA1), first reported by Burns in 1985[1], was renamed PTA1 in 1989 because of its expression on platelets as well[2]. Since 1985, a lot of investigations have been done on PTA1 expression, its functions and its relationship with diseases. PTA1, mainly expressed on activated T cells, platelets and megakaryocytes lineage, was involved in signal transduction of T cell activation and differentiation as well as platelet activation and aggregation. PTA1 mAb (Leo-A1) was found to stimulate activation and aggregation of platelets and inhibit differentiation of CTL.
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