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０ 引言 ＣＤＫ抑制剂（ｃｙｃｌｉｎ－ｄｅｐｅｎｄｅｎｔｋｉｎａｓｅｉｎｈｉｂｉｔｏｒ，ＣＤＫＩ），是细胞周期负调节因子，被认为具有抑癌基因活性．ｐ２１基因是１９９３年发现的第一个ＣＤＫＩ基因［１］，其主要作用为：抑制ＣＤＫ２，４，６等活性，推测其在细胞
0 Introduction CDK inhibitor (cyclin-dependent kinase inhibitor, CDKI), a cell cycle negative regulator, is thought to have tumor suppressor gene activity. The p21 gene is the first CDKI gene discovered in 1993 [1], its main function is: inhibit CDK2,4,6 and other activities, presumably in cells