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目的:优选经前平口服液的纯化工艺。方法:以芍药苷含量和澄清度为指标,分别用60%醇沉、ZTC-Ⅲ型天然澄清剂、壳聚糖和高速离心纯化方法处理经前平提取浓缩液,筛选出醇沉为最佳纯化方法;再采用正交设计法考察乙醇浓度、醇沉时间、醇沉液pH值对芍药苷提取效果的影响,进一步优化醇沉工艺条件。结果:醇浓度60%、醇沉12h、醇沉液pH值7.0为最佳醇沉工艺。结论:该纯化工艺简便、合理、可行,符合经前平口服液工业化大生产的要求。
Objective: To optimize the purification process of Jingqianping oral liquid. Methods: Paeoniflorin content and clarity as an indicator, respectively, with 60% alcohol precipitation, ZTC-Ⅲ natural clarifying agent, chitosan and high-speed centrifugal purification of pretreated extract concentrate was screened alcohol precipitation is the best The orthogonal design method was used to investigate the effects of ethanol concentration, alcohol precipitation time and pH value of alcohol precipitation on the extraction of paeoniflorin, and further optimize the alcohol precipitation process conditions. Results: The alcohol concentration of 60%, alcohol precipitation 12h, alcohol precipitation pH value of 7.0 for the best alcohol precipitation process. Conclusion: The purification process is simple, reasonable and feasible, in line with the pre-oral oral liquid industrial production requirements.