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环孢菌素对多种药物耐药的多发性骨髓瘤的作用难治性多发性骨髓瘤（ＭＭ）通常表现为对多种药物耐药（ＭＤＲ），因为耐药细胞的膜糖蛋白（ＰｇＰ）是ＭＤＲ－１基因产物，能消耗能量把药物泵出胞外，使长春新碱和阿霉素不能在细胞内积累，而环孢菌素可阻断ＰｇＰ的作用。...
The Role of Cyclosporine in Multiple Drug-Resistant Multiple Myeloma Refractory Multiple myeloma (MM) is commonly manifested as multidrug resistance (MDR) because the membrane glycoprotein of drug-resistant cells (PgP ) Is a product of the MDR-1 gene that consumes energy to pump the drug out of the cell, preventing vincristine and doxorubicin from accumulating inside the cell, whereas cyclosporine blocks PgP. ...