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硫代碳酰肼和氨基硫脲衍生物具有一定的生理活性,可作为某些金属离子的特效试剂,引起了人们极大的兴趣。1975年,Edward报道了在青霉素和先锋霉素中引入二茂铁基,可使抗菌活性提高。一些芳香基硫代碳酰腙和缩氨基硫脲的合成已有文献报
Carbothiohydrazide and thiosemicarbazide derivatives have certain physiological activity, which can be used as special effect reagent of some metal ions, and has aroused great interest. In 1975, Edward reported that the introduction of ferrocene groups in penicillin and cephalosporin improved antibacterial activity. Some aryl thiocarbonyl hydrazone and thiosemicarbazide synthesis has been reported in the literature