【摘 要】
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Recently, Friedmann Angeli et al.[1] reported that the loss of ferroptosis regulation enzyme glutathione peroxidase 4 (GPX4) will cause an overwhelming ferropto
【机 构】
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Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China
论文部分内容阅读
Recently, Friedmann Angeli et al.[1] reported that the loss of ferroptosis regulation enzyme glutathione peroxidase 4 (GPX4) will cause an overwhelming ferroptosis of renal cells, which eventually induces renal failure.Yet, liproxstatin-1, a novel potent ferroptosis inhibitor,is able to alleviate tissue injury of ischemia/reperfusion-induced renal injury.This study smartly expanded the research on nonapoptotic cell death, ferroptosis, as researchers were just focused on its effect on tumor and neuronal diseases before [2,3].Actually, ferroptosis is related to multiple pathophysiological processes, and triggering or inhibiting ferroptosis will be novel therapy strategies for many diseases,such as atherosclerosis, angiocardiopathy, and diabetes.In their research, the complex lipid oxidation was also investigated, which provided new possibilities for redox-target therapy [1].
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