,d(GC)n repeats form Z-DNA within promoter region and repress the promoter activity in Escherichia c

• 作 者: Shenghe Huang Chuxin WU Dongming Li Haizhou Wang Zechang Rao Qiling Shen Chunxiang Chen
• 机 构: Fuzhou Medical College,Nanchang University,Fuzhou 344000,China“,”Nanchang Teachers College,Nanchang
• 出 处: 生物化学与生物物理学报（英文版）
• 发表日期: 2015年7期
• 关键词: @@

Z-DNA is a left-handed helical form of DNA in which sugarphosphate backbone winds in a zig-zag patte.DNA containing alteating purine and pyrimidine repeats has the potential to adopt the Z-DNA formation.In vivo,Z-DNA is formed and stabilized by negative supercoil or specific Z-DNA-binding proteins.Z-DNA-forming sequences are widespread in cells,especially in the promoter regions and centromere of chromatins,so it is thought to be involved in some biological processes such as gene expression,genetic instability,and DNA processing events [1].