心肌代谢重构在慢性心力衰竭进展中的作用

• 作 者: 邱英茹
• 机 构: 哈尔滨医科大学附属第一医院,黑龙江 哈尔滨,150001
• 出 处: 心血管病学进展
• 发表日期: 2018年2期
• 关键词: Heart failure Metabolic remodeling Targeted therapy

慢性心力衰竭是一种复杂而严重的临床综合征,尽管治疗手段的进步使心力衰竭5年生存率在过去20年有所改善;但仍维持在较低水平,有大约30%的心力衰竭患者在被诊断的5年内死亡,因此,人们不断地探索心力衰竭的发病机制及防治手段.随着对慢性心力衰竭发病机制研究的不断深入,心肌代谢重构在慢性心力衰竭发生发展中的作用愈来愈被重视;但目前对如何调节心肌能量代谢认识有限.现对慢性心力衰竭时心肌代谢重构的特点及治疗手段的研究进展做一综述.“,”Chronic heart failure is a complex and severe clinical syndrome.Although the 5-year survival rate for heart failure has improved in the past 20 years by advances in treatment,these rates still remain at low levels.The mortality rate of heart failure remains at approximately 30%within 5 years of diagnosis.Therefore researchers continue to explore the pathogenesis and prevention for heart failure. With increasing pathogenesis of chronic heart failure,myocardial metabolic remodeling is recognized as contributing to the development of heart failure.However,how to regulate myocardial energy metabolism is limited.In this review,we will discuss the characteristics of myocardial metabolic remodeling and the progression of therapeutic approaches in chronic heart failure.