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为了探讨新生儿肾小管功能变化特点及测定尿视黄醇结合蛋白（RBP）的正常值，本文对1—10天内4个日龄组的114例正常新生儿进行了尿RBP、尿Cr测定并计算尿RBP／Cr比值。结果显示随着日龄的增加尿RBP有逐渐下降的趋势（～1d0．042±0．018mg／L、～3d0．035±0．019mg／L、～7d0．038±0．026／L），7天后明显下降（7～10d0．026±0．022mg／L）。说明7天后新生儿肾小管重吸收功能明显完善。本研究测得的尿RBP95％可信限的正常范围是：7天内小于0．0811mg／L、7天后小于0．0699mg／L。尿RBP／Cr比值在～7天组形成一个峰值，7天后也显著下降，与尿RBP相比尿RBP／Cr比值更灵敏地反映了肾小管功能在7天左右的变化。本文为窒息时肾小管损害提供了一个更灵敏的监测指标。
In order to investigate the changes of renal tubular function in neonates and to determine the normal value of urinary retinol binding protein (RBP), urinary RBP and urinary Cr were measured in 114 normal newborns of four days of age in 1-10 days Calculate urinary RBP / Cr ratio. The results showed that the urinary RBP tended to decrease gradually with the increase of age (~ 1d0.042 ± 0.018mg / L, ~ 3d0.035 ± 0.019mg / L, ~ 7d0.038 ± 0.026 / L) After 7 days decreased significantly (7 ~ 10d0.026 ± 0.022mg / L). 7 days after renal tubular reabsorption significantly improved. The normal range of 95% confidence limits for urinary RBP measured in this study was less than 0.0811 mg / L for 7 days and less than 0.0699 mg / L for 7 days. The urinary RBP / Cr ratio peaked at ~ 7 days and decreased significantly after 7 days. Compared with urinary RBP, urinary RBP / Cr ratio more sensitively reflected changes in renal tubular function over a 7-day period. This article provides a more sensitive indicator of renal tubular damage during asphyxia.