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在大疱性疾病中,均有自身抗体和(或)补体在皮肤的特定位置上沉积,除了这些特异性、诊断性免疫组织学特征外,每种疾病还有特征性的组织病理学表现,其中包括皮肤炎症性单核细胞浸润等.作者应用单克隆抗体和间接免疫过氧化酶技术对各种大疱性皮损的边缘进行活检,计数T细胞及其亚群、B细胞、巨噬细胞和郎格罕细胞/树枝状细胞的绝对数和相对数.同时以正常皮肤(NS)对照.
In bullous diseases, autoantibodies and / or complement are deposited at specific locations on the skin. In addition to these specific, diagnostic immunohistological features, each disease has a characteristic histopathological appearance, Including inflammatory infiltration of mononuclear cells, etc. The authors used monoclonal antibodies and indirect immunoperoxidase techniques to biopsy the margins of various bullous lesions, counting T cells and their subsets, B cells, macrophages And absolute and relative numbers of Langerhans cells / dendritic cells, with normal skin (NS) controls.