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目的研究传统机械法和激光法两种辅助孵化技术对冻融胚胎移植的种植率和临床妊娠率的影响,并对比两种方法的差异。方法 147例FET患者共分为3组,PZD组(n=48)胚胎透明带采用PZD方法削薄;LAH组(n=62)胚胎采用LAH方法削薄;对照组(n=37)不采用任何辅助孵化技术,直接移植。比较三组的种植率和临床妊娠率。结果 PZD组和LAH组种植率均高于对照组(22.4%、23.6%vs 10%,P<0.05),LAH组临床妊娠率高于对照组(43.5%vs 21.6%,P<0.05)。两种方法之间在种植率、临床妊娠率和多胎率方面均无差异(22.4%vs 23.6%;39.6%vs 43.5%;42.1%vs 29.6%。P>0.05)。结论 PZD和LAH法均可提高冻融胚胎种植率,两种方法之间无差异。
Objective To study the effect of traditional mechanical and laser assisted hatching techniques on the implantation rate and clinical pregnancy rate of frozen-thawed embryos, and to compare the differences between the two methods. Methods A total of 147 FET patients were divided into 3 groups. The PZD group (n = 48) was thinned by PZD method. LAH group (n = 62) was thinned by LAH method. Any assisted hatching technique, direct transplant. Comparison of three groups of planting rate and clinical pregnancy rate. Results The implantation rate in PZD group and LAH group was higher than that in control group (22.4%, 23.6% vs 10%, P <0.05). The clinical pregnancy rate in LAH group was higher than that in control group (43.5% vs 21.6%, P <0.05). There was no difference between the two methods in terms of implantation rate, clinical pregnancy rate and multiple pregnancy rate (22.4% vs 23.6%; 39.6% vs 43.5%; 42.1% vs 29.6%, P> 0.05). Conclusion Both PZD and LAH methods can improve the implantation rate of frozen-thawed embryos, with no difference between the two methods.