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目的通过对前来我院就诊的1058例有不育不孕、反复流产史的患者作细胞遗传学分析,为临床诊断提供遗传学实验依据。方法外周血细胞培养,制片,G显带,核型分析。结果 1058例患者,女640例,男418例,共检出染色体异常57例,检出率为5.38%,其中异常核型26例,占染色体异常的45.6%;染色体多态性31例,占染色体异常的54.4%。结论染色体异常是引起不育不孕,反复流产的主要原因,应加强对不良孕产史,反复流产的夫妇行外周血细胞染色体检查,以减少遗传病患儿的出生。
Objective To provide cytogenetic analysis of 1058 patients with infertility and recurrent abortion who come to our hospital to provide genetic basis for clinical diagnosis. Methods Peripheral blood cell culture, preparation, G - banding and karyotype analysis. Results A total of 1058 patients, 640 males and 418 females, 57 cases of chromosomal abnormalities were detected, the detection rate was 5.38%, of which 26 cases were abnormal karyotypes, accounting for 45.6% of chromosomal abnormalities; 31 cases of chromosomal polymorphisms 54.4% of chromosomal abnormalities. Conclusion Chromosomal abnormalities are the main causes of infertility and recurrent miscarriage. Chromosome examination of peripheral blood cells in couples with abnormal pregnancy history and recurrent abortion should be strengthened to reduce the birth of children with inherited diseases.