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对乙型肝炎72例小儿患者肝组织标本,用免疫组织化学方法(ABC法)检测肝内HBsAg和HBcAg的显现情况,并与成人乙型肝炎101例患者肝组织的检验结果进行比较。结果显示,小儿乙肝时肝内HBsAg和HBcAg的显现与成人有所不同:(1)小儿肝HBcAg阳性率显著低于成人;(2)在阳性病例中,小儿肝内HBsAg或HBcAg阳性细胞数显著少于成人。这可能反映小儿HBV感染时,乙肝病毒抗原表达比成人少。
The liver samples of 72 pediatric patients with hepatitis B were detected by immunohistochemistry (ABC method) to detect the presence of HBsAg and HBcAg in the liver and compared with the results of liver tissue in 101 patients with adult hepatitis B virus. The results showed that the appearance of HBsAg and HBcAg in children with hepatitis B was different from that in adults: (1) The positive rate of HBcAg in children was significantly lower than that in adults; (2) In positive cases, the number of HBsAg or HBcAg positive cells in infants was significant Less than adults. This may reflect the hepatitis B virus infection in children, hepatitis B virus antigen expression less than adults.