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骨形态发生蛋白 (BMPs)属于转化生长因子 -β(TGF-β)超家族的成员 ,最初因其能促进成骨细胞、成软骨细胞的分化和诱导异位骨的形成而得名。随着研究的深入 ,BMPs的广泛生物学功能不仅限于其诱导成骨活性 ,而且涉及几乎全身所有系统的发育和形成 ,包括心血管、胃肠、呼吸、泌尿生殖、体被及神经系统的胚胎发育、生长及分化等。 BMP- 6是 BMPs家族成员中之一 ,除了具有 BMP家族的一些特征外 ,还有其独特的分子生物学功能。本文主要阐述了 BMP- 6在近五年中的研究进展 ,包括其结构特征、信号的传递、生物学功能的多样性及其临床应用前景。
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily and were originally named for their ability to promote the differentiation of osteoblasts and chondroblasts and to induce the formation of heterotopic bone. With further research, the extensive biological function of BMPs is not limited to its induction of osteogenic activity, but also to the development and formation of almost all systemic systems, including cardiovascular, gastrointestinal, respiratory, genito-urinary, body and nervous system embryos Development, growth and differentiation. BMP-6 is a member of the BMPs family, in addition to some features of the BMP family, but also has its unique molecular biology. This article mainly expounds the research progress of BMP-6 in the past five years, including its structural characteristics, signal transmission, the diversity of biological functions and its clinical application prospects.