国产甲氟哌酸的药效学研究

• 作 者: 余兰香 熊雁琼 刘京芳 林赴田
• 机 构: 中国医学科学院医药生物技术研究所,中国医学科学院医药生物技术研究所,中国医学科学院医药生物技术研究所,中国医学科学院医药生物技术研究所 北京100050,北京100050,北京100050,北京100
• 出 处: 中国新药杂志
• 发表日期: 1993年01期
• 关键词: 甲氟哌酸 肺炎杆菌 绿脓杆菌 抗菌活性 动物感染 大肠杆菌 药效学 致病菌 强于 敏感性

测定了甲氟哌酸(Pefloxacin)的抗菌谱,临床分离致病菌敏感性和感染动物的保护作用。结果表明,甲氟哌酸对 G~+菌和 G~-菌均有良好的抗菌作用,对临床分离金葡菌的 MIC_(50)为0.39μg/ml,大肠杆菌为0.19μg/ml,变形杆菌和肺炎杆菌分别为0.78μg/ml和0.39μg/ml,绿脓杆菌为6.5μg/ml。甲氟哌酸的抗菌活性与氟啶酸和氟哌酸(Nofloxacin)相似。小鼠分别感染金葡菌、大肠杆菌、肺炎杆菌和绿脓杆菌的保护效果明显强于氟哌酸。

The antibacterial spectrum of Pefloxacin, the sensitivity of pathogens isolated from clinical isolates and the protective effect of infected animals were determined. The results showed that mefloxacin had a good antibacterial effect on G ~ + and G ~ - bacteria. The MIC50 of Staphylococcus aureus was 0.39μg / ml and that of E.coli was 0.19μg / ml. Bacillus and Klebsiella pneumoniae were 0.78 μg / ml and 0.39 μg / ml, respectively, and Pseudomonas aeruginosa was 6.5 μg / ml. The antibacterial activity of cilofloxacin is similar to that of nifedipine and nofloxacin. The mice were infected with Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa protective effect was significantly stronger than norfloxacin.