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抗结核药利福平能增加肝微粒体酶的活性,据报道利福平药物相互影响的数目在增加。有些研究表明用利福平治疗能降低血清甲状腺素的浓度,而血清 T_3水平不降低,基础的或刺激后释放的促甲状腺激素水平不变。利福平诱导的微粒体酶系统活性增加可由安替比林的清除增加而得到证明.许多作者在使用已知能刺激肝药物代谢微粒体酶系统的另外两种药物-苯妥英和氨甲酰氮(艹卓)——治疗时都可观察到血清 T_4的减少。由于部分甲状腺激素是在肝微粒体酶
Rifampicin, an anti-tuberculosis drug, increases the activity of liver microsomal enzymes, and the number of rifampicin medications reportedly increases. Some studies have shown that treatment with rifampicin can reduce serum thyroxine concentrations, while serum T_3 levels do not decrease, basal or stimulated release of thyroid stimulating hormone levels unchanged. Rifampicin-induced increases in microsomal enzyme system activity are evidenced by the increased clearance of antipyrine.Many authors have used two other drugs, phenytoin and carbamazamide, known to stimulate hepatic drug metabolism microsomal enzyme systems艹 Zhuo) - treatment can be observed when the serum T_4 reduction. Since some thyroid hormones are in the liver microsomal enzyme