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发生于慢性粒细胞性白血病(CML)母细胞危象期(BC,即急变期)的染色体畸变并不少见,其最常见的类型为:8三体、i(17q)和/或Ph~1重复。大约 85％的CML患者,至少有上述一种改变。本文作者曾报告,在慢性期经强烈化疗的患者,约50％的病例有1号染色体的附加的结构改变。本文研究表明,CML患者的1号染色体仅仅某些部位选择性地受累,此类患者预后不良。材料和方法本文报告7例Ph~1阳性的CML患者,其1号染色体异常出现于急变期。这些患者选自本实验室1972年以来研究的一组50例Ph~1
It is not uncommon for chromosomal aberrations that occur in the crisis phase of chronic myelogenous leukemia (CML) blasts (BC, the blastic phase), with the most common types being trisomy 8, i (17q) and / or Ph ~ 1 repeat. About 85% of CML patients have at least one of these changes. The authors of this report have reported that in patients with intensive chemotherapy in chronic phase, about 50% of cases have additional structural changes on chromosome 1. This study shows that CML patients with chromosome 1 only selectively affected some areas, such patients with poor prognosis. Materials and Methods In this paper, 7 cases of Ph-1-positive CML patients were reported. The abnormality of chromosome 1 occurred in the blastic phase. These patients were selected from a group of 50 Ph ~ 1 studies in our laboratory since 1972