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本文报告3例懒惰白细胞综合征(LLS)。例1,10个月女孩。患儿从新生儿期起反复发生口内炎,咽喉炎及皮肤化脓症,且常形成皮肤脓疡。生后10月发现中性粒细胞(1%)减少而白细胞总数正常,骨髓粒系细胞数及其形态均无异常,IgG、IgM、IgA,C_3均正常,T细胞80%,B细胞7%。白细胞趋化性低于正常,任意运动也降低,对氢化考的松及肾上腺素的刺激反应不良,而中性粒细胞的吞噬功能及杀菌能力正常。骨髓CFU-C较健康儿高,淋巴细胞转化率正常,PHA皮内试验阳性,淋巴细胞衍行趋化因子(LDCF)产生能力正常。SMZ-TMP合剂及维生素C(Vitc)治疗后临床经过良好。例2,8个月男孩。生后4个月起反复发生口内炎、扁桃体炎,无皮肤化脓症,末梢血中性粒细胞减少
This article reports three cases of lazy leukocyte syndrome (LLS). Example 1, 10-month girl. Children from the neonatal recurrence of stomatitis, pharyngitis and purulent skin, and often the formation of skin abscess. The number of neutrophil granulocytes and its morphology were normal in all cases, IgG, IgM, IgA and C_3 were all normal, 80% of T cells, 7% of B cells, . Leukocyte chemotaxis is lower than normal, any exercise is also reduced, hydrogenation of cortisone and adrenergic stimulation of poor response, and neutrophil phagocytosis and bactericidal ability of normal. Bone marrow CFU-C than healthy children, lymphocyte transformation rate was normal, PHA intradermal test positive, lymphocyte derived chemokine (LDCF) production capacity of normal. SMZ-TMP mixture and vitamin C (Vitc) treatment after a good clinical. Example 2, 8 months boy. 4 months after birth recurrence of endophthalmitis, tonsillitis, no purulent skin, peripheral blood neutropenia