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目的:观察联合用药对幽门螺杆菌感染并发胃溃疡的近远期疗效,以供临床参考。方法:以2008年10月～2011年9月在我院内科接受治疗的幽门螺杆菌感染并发胃溃疡患者91例为研究对象,进行随机分组,均给予奥美拉唑、阿莫西林、胶体果胶铋三联疗法治疗,观察组在此基础上加服替硝唑。观察两组的临床疗效,随访12个月,比较两组复发率的差异。结果:两组患者均取得了一定的治疗效果。与对照组相比较,观察组总有效率较高,复发率较低,有显著的统计学差异(p<0.05)。结论:采用质子泵抑制剂、抗生素、胃黏膜保护剂联合疗法治疗幽门螺杆菌感染并发胃溃疡,临床疗效较为满意,其中,两种抗生素联合应用对患者的康复具有更好的促进作用,可在今后的临床工作中予以推广。
Objective: To observe the short-term and long-term effects of combination therapy on Helicobacter pylori infection complicated with gastric ulcer for clinical reference. Methods: From October 2008 to September 2011 in our hospital medical treatment of Helicobacter pylori infection in patients with gastric ulcer in 91 cases of patients were randomly divided into groups, were given omeprazole, amoxicillin, colloidal fruit Gel bismuth triple therapy, the observation group on this basis plus tinidazole. The clinical efficacy of the two groups were observed and followed up for 12 months. The difference of recurrence rate was compared between the two groups. Results: Two groups of patients have achieved some therapeutic effect. Compared with the control group, the observation group had a higher total effective rate and a lower recurrence rate, with significant statistical difference (p <0.05). Conclusion: The combination of proton pump inhibitors, antibiotics and gastric mucosal protective agent combination therapy for the treatment of Helicobacter pylori infection complicated with gastric ulcer, the clinical efficacy is satisfactory, in which the combination of two antibiotics has a better role in promoting the rehabilitation of patients, In the future clinical work to be promoted.