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目的观察神经阻滞联合阿昔洛韦治疗带状疱疹的疗效。方法将80例带状疱疹患分为观察组46例和对照组34例,分别采用神经阻滞联合阿昔洛韦治疗和单纯阿昔洛韦治疗,采用VAS法评定疼痛程度,采用PSQI评价睡眠质量,并统计比较总有效率。结果与治疗前相比,观察组治疗后3d、1周、2周和4周VAS评分均发生显著变化,差异有统计学意义(均P<0.05);对照组治疗后2周和4周VAS评分才发生显著变化差异有统计学意义(均P<0.05)。观察组治疗后3d、1周、2周和4周VAS评分均低于对照组,差异有统计学意义(P<0.05)。与治疗前相比,观察组治疗后1周、2周和4周PSQI评分均发生显著变化,差异有统计学意义(均P<0.05);对照组治疗后2周和4周PSQI评分发生显著变化,差异有统计学意义(均P<0.05)。观察组治疗后1周、2周和4周PSQI评分均低于对照组,差异有统计学意义(P<0.05)。观察组总有效率为97.8%优于对照组的76.5%,差异有统计学意义(P<0.05)。结论神经阻滞联合阿昔洛韦能短期内减轻带状疱疹患者的疼痛和改善睡眠质量,临床疗效好,具有很好的临床应用价值。
Objective To observe the efficacy of nerve block combined with acyclovir in the treatment of shingles. Methods Eighty patients with herpes zoster were divided into observation group (n = 46) and control group (n = 34). Nerve block combined with acyclovir and acyclovir were respectively used. VAS method was used to assess the degree of pain. PSQI was used to evaluate sleep Quality, and statistics to compare the total efficiency. Results Compared with those before treatment, VAS scores in observation group changed significantly at 3d, 1 week, 2 weeks and 4 weeks after treatment (both P <0.05), and VAS scores in control group at 2 weeks and 4 weeks after treatment There was significant difference between the scores (P <0.05). The VAS scores in the observation group at 3d, 1, 2 and 4 weeks after treatment were lower than those in the control group, with statistical significance (P <0.05). Compared with before treatment, the PSQI scores of the observation group changed significantly at 1 week, 2 weeks and 4 weeks after treatment, the difference was statistically significant (both P <0.05); the PSQI scores of the control group were significant at 2 weeks and 4 weeks after treatment Change, the difference was statistically significant (all P <0.05). The scores of PSQI in observation group at one week, two weeks and four weeks after treatment were all lower than those in control group (P <0.05). The total effective rate in observation group was 97.8%, which was significantly higher than 76.5% in control group (P <0.05). Conclusion Nerve block combined with acyclovir can shorten the pain and improve the quality of sleep in patients with herpes zoster, with good clinical curative effect and good clinical value.