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目的观察糖皮质激素对于多发性硬化(multiple sclerosis,MS)患者脑脊液IgG的影响。方法 26例复发-缓解型MS患者,急性期查脑脊液IgG寡克隆区带(IgG oligoclonal band,Ig G-OB)和IgG指数(IgG index,IgGI),激素治疗7周后复查。结果治疗前后IgG-OB阳性率下降(73.08%vs 18.18%,χ2=17.541,P=0.000);相关系数R=0.502,P=0.000。治疗前后IgGI下降(1.38±0.44 vs 0.55±0.18,t=9.790,P=0.016)。结论 MS急性期用糖皮质激素可以降低鞘内IgG合成,从而控制病情进展。
Objective To investigate the effect of glucocorticoids on cerebrospinal fluid IgG in patients with multiple sclerosis (MS). Methods Twenty - six patients with relapsing - remitting MS were enrolled in this study. IgG oligoclonal band (IgG) and IgG index (IgGI) were collected from patients with cerebrospinal fluid during the acute phase. Hormone therapy was followed up for 7 weeks. Results The positive rate of IgG-OB decreased before and after treatment (73.08% vs 18.18%, χ2 = 17.541, P = 0.000). The correlation coefficient R = 0.502, P = 0.000. IgGI decreased before and after treatment (1.38 ± 0.44 vs 0.55 ± 0.18, t = 9.790, P = 0.016). Conclusion MS acute phase glucocorticoid can reduce intrathecal IgG synthesis, thereby controlling the progression of the disease.