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目的探讨血清尿酸水平和尿酸/肌酐比值监测在评估COPD稳定期病情变化中的意义。方法选取2012年2月至2014年3月间就诊的稳定期COPD患者207例,根据GOLD分级标准:1级50例,2级53例,3级57例,4级47例。同期选取体检中心健康体检者60例。利用肺功能仪对所有患者肺功能进行检测,利用全自动生化分析仪对血清尿酸和肌酐水平进行检测。结果 COPD患者血尿酸水平和尿酸/肌酐比值分别为(374.36±55.14)μmol/L和(6.44±1.03),均高于健康者,差异均具有统计学意义(P<0.05);不同GOLD分级COPD患者血尿酸水平和尿酸/肌酐比值差异均具有统计学意义(P<0.05),经LSD-t两两比较,4级>3级>2级>1级;Pearson相关分析显示,COPD患者FEV1与血尿酸水平、尿酸/肌酐比值均呈负相关(r=-0.317和-0.406,均P<0.05)。结论血清尿酸水平和尿酸/肌酐比值在稳定期COPD患者升高,且与患者病情严重程度呈正相关,可作为评估患者病情的参考指标。
Objective To investigate the significance of serum uric acid level and uric acid / creatinine ratio in assessing the changes of COPD in stable phase. Methods A total of 207 stable COPD patients were selected from February 2012 to March 2014. According to the GOLD grading standards, 50 patients in grade 1, 53 patients in grade 2, 57 patients in grade 3 and 47 patients in grade 4 were included in this study. In the same period, 60 cases of physical examination were selected. Pulmonary function tests were performed on all patients with pulmonary function and serum uric acid and creatinine levels were measured using an automated biochemical analyzer. Results The levels of serum uric acid and creatinine / creatinine were (374.36 ± 55.14) μmol / L and (6.44 ± 1.03) respectively in COPD patients, which were significantly higher than those in healthy controls (P <0.05) The level of serum uric acid and the ratio of uric acid / creatinine in patients with COPD were significantly different (P <0.05). The LSD-t was no significant difference (P> 0.05) Serum uric acid level, uric acid / creatinine ratio were negatively correlated (r = -0.317 and -0.406, all P <0.05). Conclusions Serum uric acid level and uric acid / creatinine ratio are elevated in patients with stable COPD and positively correlated with the severity of the disease, which can be used as a reference index to evaluate the patient’s condition.