论文部分内容阅读
目的探讨宫颈上皮内瘤样病变(CIN)患者人乳头瘤病毒(HPV)感染状况。方法选取诸暨市中医院收治的CIN患者237例,记录CIN患者HPV感染情况,包括感染率、分型、感染类型、基因型。结果 CIN患者237例,HPV感染192例,占81.01%,CINⅠ、CINⅡ、CINⅢ患者的HPV感染率分别为73.85%、86.21%、93.88%。192例HPV感染患者中,高危型HPV感染171例(89.06%),低危型HPV感染21例(10.94%),其中单一感染118例(61.46%),多重感染74例(38.54%),CINⅠ、CINⅡ、CINⅢ患者的高危型HPV感染率分别为84.38%、90.00%、97.83%,多重感染率分别为30.21%、42.00%、52.17%。192例HPV感染患者的前5位基因型分别为16、58、52、33、31型,CINⅠ患者的前5位基因型分别为16、58、52、18、31型,CINⅡ患者的前5位基因型分别为16、58、52、33、18型,CINⅢ患者的前5位基因型分别为16、52、58、33、31型。结论 CIN患者感染HPV的风险较高,且以高危型16、58、52型感染和多重感染为主,临床上应加强HPV监测,及时进行对症治疗。
Objective To investigate the status of human papillomavirus (HPV) infection in patients with cervical intraepithelial neoplasia (CIN). Methods A total of 237 CIN patients admitted to Zhuji Chinese Medicine Hospital were enrolled in this study. The HPV infection status, including infection rate, typing, infection type and genotype were recorded. Results There were 237 cases of CIN and 192 cases of HPV infection, accounting for 81.01%. The infection rates of CINⅠ, CINⅡ and CINⅢ were 73.85%, 86.21% and 93.88% respectively. Of the 192 cases of HPV infection, 171 (89.06%) were high-risk HPVs and 21 (10.94%) were low-risk HPVs, of which 118 (61.46%) were single infections, 74 (38.54%) were multiple infections, The infection rates of high-risk HPV in CINⅡ and CINⅢ patients were 84.38%, 90.00% and 97.83%, respectively. The multiple infection rates were 30.21%, 42.00% and 52.17% respectively. The top 5 genotypes of 192 HPV-infected patients were 16, 58, 52, 33, and 31 respectively. The top 5 genotypes of CIN I patients were 16, 58, 52, 18 and 31, respectively. The genotypes were 16, 58, 52, 33 and 18, respectively. The top 5 genotypes of patients with CIN Ⅲ were 16, 52, 58, 33 and 31, respectively. Conclusions The risk of HPV infection in CIN patients is high. High-risk HPV types 16, 58 and 52 and multiple infections are the major risk factors. HPV surveillance should be strengthened and symptomatic treatment should be timely.