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自Ringer 发现Ca~(2+)在维持心肌收缩中的重要性以来,已有100多年;然而,Ca~(2+)的信使功能最近才得到重视。这种功能是通过细胞的下列三种表现来表达:(1)静息状态时细胞内游离Ca~(2+)浓度低下(≤10~(-7)M),兴奋时则增加到10~(-7)和10~(-5)M 之间;(2)细胞内存在有特异性Ca~(2+)结合蛋白,作为细胞内的Ca~(2+)受体,其解离常数在10~(-7)和10~(-5)M 之间;(3)在浆膜和细胞器内,有Ca~(2+)特异的流出、流入和隔绝过程,使兴奋时细胞内Ca~(2+)浓度增加,静息时则回复和保持在低水平。细胞内Ca~(2+)通过能量-依赖性
More than 100 years have passed since Ringer discovered the importance of Ca ~ (2+) in maintaining myocardial contractility; however, the messenger function of Ca ~ (2) has only recently received attention. This function is expressed by the following three manifestations of cells: (1) resting Ca 2+ concentration (≤10 ~ (-7) M) in the cells and increased to 10 ~ (-7) and 10 ~ (-5) M respectively. (2) There is a specific Ca2 + -binding protein in cells, which is a Ca2 + receptor in cells with a dissociation constant Between 10 ~ (-7) and 10 ~ (-5) M; (3) In the serosa and organelles, there are Ca ~ (2+) specific efflux, influx and isolation process, ~ (2+) concentration increased, rest and rest at rest at a low level. Intracellular Ca ~ (2+) energy-dependent