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八十年代以来不少学者应用2400mosmol/L高渗盐水治疗低血容量性休克获得满意效果,但机理未明。本工作在家免肠系膜上动脉闭塞性休克(SMAO休克)模型上,比较高渗盐水与高渗葡萄糖液和不同浓度盐水的抗休克作用,以探讨高渗盐水的抗休克机理。 雄兔40只,局麻下开腹用无创止血钳夹闭肠系膜上动脉一小时,然后开夹恢复肠道血流,造成SMAO休克。动物随机分组,每组10只。①高盐组:于开夹后15分钟内输入2400mosol/L NaCl液5ml/kg,其后60分钟内输入生理盐水55ml/kg;②
Since the eighties many scholars use 2400 mosmol / L hypertonic saline treatment of hypovolemic shock obtained satisfactory results, but the mechanism is unknown. In this study, we investigated the anti-shock effect of hypertonic saline on hypertensive saline (SMAO shock) model and compared the anti-shock effects of hypertonic saline with hypertonic glucose solution and different concentrations of saline. Male rabbits 40, under local anesthesia open non-invasive hemostatic clamp occlusion of the superior mesenteric artery for one hour, and then open the folder to restore intestinal blood flow, resulting in SMAO shock. Animals were randomly divided into groups of 10. ① In the high-salt group, 2400mlol / L NaCl solution (5ml / kg) was infused within 15 minutes after opening the clamp, and saline (55ml / kg) was infused within 60 minutes.