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目的 :分析原发性肾病综合征 ( NS)合并急性肾衰 ( ARF)的发病因素、特征、治疗和预后。方法 :全部病例检查尿蛋白定量、生化指标及血流变学 ,1 9列进行了肾活检。结果 :发病年龄多在 45岁以下 ( 85.74% ) ,男性为 80 % ,1 9例肾活检结果以轻微病变为多 ( 68.42 % ) ,均有肾间质水肿和肾小管细胞的变性、坏死。予以激素、利尿剂及尿激酶治疗 ,个别人进行血液透析后取得满意效果。结论 :NS合并 ARF发病年龄轻 ,病理以轻微病变多见 ,经尿激酶和常规治疗肾功能多可恢复 ,提示肾内微血栓形成不可忽视
Objective: To analyze the etiopathogenesis, characteristics, treatment and prognosis of primary nephrotic syndrome (NS) complicated with acute renal failure (ARF). Methods: All cases were examined urinary protein, biochemical indicators and hemorrheology, renal biopsy was performed in 19 cases. Results: The age of onset was mostly below 45 years old (85.74%), 80% for men, and 19 cases (68.42%) with slight lesions on renal biopsy. All of them had renal interstitial edema and degeneration and necrosis of renal tubular cells. To hormone, diuretic and urokinase treatment, individual hemodialysis obtained satisfactory results. Conclusions: The age of NS combined with ARF is mild, and the pathology is more common in mild and pathological changes. Renal function can be restored by urokinase and routine therapy, which suggests that the intrarenal micro-thrombosis can not be neglected