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目的探讨妊娠高血压综合征(妊高征)患者血浆超敏C反应蛋白(Hs-CRP)、血浆凝血酶调节蛋白(TM)和血浆D-二聚体水平的变化及三者在妊高征时联合检测的应用价值。方法采用双抗体夹心酶联免疫吸附法(ELISA法)检测64例妊高征患者和71例正常晚期妊娠妇女的血浆TM含量,采用德国美创MED-4600型全自动血凝仪检测研究对象的血浆D-二聚体水平,免疫透射比浊法检测超敏C反应蛋白(Hs-CRP)的含量变化,并作统计分析。结果妊高征患者血浆Hs-CRP含量、血浆TM和血浆D-二聚体水平明显高于正常妊娠组(P值均<0.01),且与病情的严重程度呈高度正相关。结论血浆Hs-CRP、血浆TM和D-二聚体可能参与了妊高征患者血管内皮损伤的过程,三者联合检测或可作为妊高征诊断和病情观察的实验室敏感指标。
Objective To investigate the changes of plasma high-sensitivity C-reactive protein (Hs-CRP), plasma thrombin regulatory protein (TM) and plasma D-dimer in patients with pregnancy induced hypertension (PIH) When the joint detection of the value. Methods The plasma levels of plasma TM in 64 cases of PIH and 71 normal pregnant women were measured by ELISA. The serum samples were collected by MED-4600 automatic coagulation analyzer Plasma D-dimer level and immunostaining turbidimetry were used to detect the content of Hs-CRP. Statistical analysis was performed. Results The levels of Hs-CRP, plasma TM and plasma D-dimer in patients with PIH were significantly higher than those in normal pregnancy (P <0.01), and were positively correlated with the severity of PIH. Conclusions Plasma Hs-CRP, plasma TM and D-dimer may be involved in the process of endothelial dysfunction in patients with PIH. The combined detection of Hs-CRP and plasma D-dimer may be used as a laboratory sensitive index for the diagnosis and observation of PIH.