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目的探讨缩宫素不同使用方法在重度子痫前期剖宫产术中的应用效果及安全性。方法选取2012年3月至2014年5月陕西省人民医院产科收治的124例重度子痫前期患者的临床资料,根据不同治疗方法分为对照组、观察组各62例。对照组采取单纯的宫体注射缩宫素治疗;观察组在对照组基础上给予缩宫素静脉滴注治疗。观察两组患者在术中以及术后的出血情况、住院时间、肛门排气时间、下地活动时间及术中不良反应发生情况。结果观察组患者术中、术后2 h、术后24 h出血量分别为(368±35.7)m L、(112±18.7)m L、(467±50.4)m L,低于对照组[分别为(445±34.5)m L、(174±20.5)m L、(610±75.3)m L](P<0.05);观察组患者术中不良反应发生率(14.5%)低于对照组(46.8%)(P<0.05);对照组与观察组患者的住院时间分别为(7.8±1.35)d、(5.6±0.96)d,肛门排气时间分别为(42.2±4.85)h、(30.4±4.57)h,下床活动时间分别为(31.5±2.68)h、(23.8±2.57)h,两组比较差异有统计学意义(P<0.05)。结论宫体注射缩宫素联合缩宫素静脉滴注可以有效降低重度子痫前期患者剖宫产术中、术后的出血量及不良反应的发生,提高患者的各项临床指标。
Objective To investigate the effect and safety of different oxytocin administration methods in cesarean section in severe preeclampsia. Methods The clinical data of 124 patients with severe preeclampsia admitted to the obstetrics department of Shaanxi Provincial People’s Hospital from March 2012 to May 2014 were divided into control group and observation group according to different treatment methods. The control group to take a simple injection of oxytocin uterine body; observation group on the basis of the control group given oxytocin intravenous infusion therapy. Two groups of patients were observed intraoperative and postoperative bleeding, hospital stay, anal exhaust time, floor activities and adverse reactions during operation. Results The intraoperative, postoperative 2 h and 24 h postoperative bleeding rates in the observation group were (368 ± 35.7) m L, (112 ± 18.7) m L and (467 ± 50.4) m L, respectively, lower than those in the control group (445 ± 34.5) m L, (174 ± 20.5) m L, (610 ± 75.3) m L] (P <0.05). The incidence of adverse reactions in the observation group was lower than that in the control group %) (P <0.05). The length of stay in the control group and the observation group were (7.8 ± 1.35) days and (5.6 ± 0.96) days respectively, and the time of anal exhaust was (42.2 ± 4.85) h and (30.4 ± 4.57) days respectively ) h, and the time for getting out of bed were (31.5 ± 2.68) h and (23.8 ± 2.57) h, respectively. There was significant difference between the two groups (P <0.05). Conclusion Intrauterine injection of oxytocin combined with oxytocin intravenously can effectively reduce the incidence of postoperative bleeding and adverse reactions during cesarean section in patients with severe preeclampsia and improve the clinical indicators of patients.