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目的探讨TORCH病原体感染与自然流产的相关性,分析其可能的影响因素。方法对2012年9月至2014年9月于四川省人民医院就诊的831例妇女采用化学发光法进行TORCH-Ig M及Ig G四项检测,将363例有自然流产史的妇女纳入A组,468例无自然流产史妇女纳入B组,比较两组TORCH感染阳性率及影响因素。结果 A组妇女HSV-Ig G(64.4%)、CMV-Ig M(5.0%)Tox-Ig M(5.8%)及HSVIg M(9.1%)抗体的阳性率均高于B组(分别为57.1%、1.9%、2.6%、5.6%)(P<0.05)。在A组中,农村妇女巨细胞病毒(cytomegalovirus,CMV)、弓形虫(toxoplasma,Tox)、风疹病毒(rubella virus,RV)、生殖器单纯疱疹病毒(herpes simplex virus,HSV)病原体的感染率分别为7.1%、7.6%、7.6%、12.1%均高于城市(2.4%、1.8%、3.6%、4.4%)(P<0.05);有动物接触史的妇女TORCH检出率高于无动物接触史的妇女(P<0.05)。结论 TORCH病原体感染与自然流产密切相关,农村、有动物接触史为TORCH感染的高危因素。
Objective To investigate the correlation between TORCH pathogen infection and spontaneous abortion and analyze its possible influencing factors. Methods 831 women from Sichuan Provincial People’s Hospital from September 2012 to September 2014 were tested by chemiluminescence method for TORCH-Ig M and Ig G. 363 women with spontaneous abortion were included in group A, 468 women without history of spontaneous abortion were enrolled in group B. The positive rate of TORCH infection and its influencing factors were compared between the two groups. Results The positive rates of HSV-Ig G (64.4%), CMV-Ig M (5.0%) Tox-Ig M (5.8%) and HSVIg M (9.1%) in group A were significantly higher than those in group B (57.1% , 1.9%, 2.6%, 5.6%) (P <0.05). In group A, the infection rates of the cytomegalovirus (CMV), toxoplasma (Tox), rubella virus (RV) and herpes simplex virus (HSV) in rural women were 7.1%, 7.6%, 7.6% and 12.1% were higher than those in urban areas (2.4%, 1.8%, 3.6% and 4.4% respectively) (P <0.05) Of women (P <0.05). Conclusion TORCH pathogen infection is closely related to spontaneous abortion. In rural areas, history of exposure to animals is a high risk factor for TORCH infection.