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目的:了解乐清市育龄妇女宫颈脱落细胞人乳头瘤病毒(human papillomavirus,HPV)感染情况,提高女性对相关疾病预警和发生的重视,同时为诊治宫颈病变提供参考依据。方法:用专用宫颈刷取妇女宫颈脱落细胞,利用基因芯片技术检测23种HPV亚型。结果:3101例患者中检出HPV感染1013例,阳性率32.67%。其中宫颈上皮内瘤样变(cervical intraepithelial neoplasia,CIN)患者阳性率明显高于宫颈炎、宫颈湿疣(P<0.05),但宫颈炎与宫颈湿疣之间无差别(P>0.05),不同级别CIN之间有差别(P<0.05)。HPV阳性患者中基因型以高危型为主,前5位是HPV16、52、58、18和33;低危型以HPV6、11为主。宫颈癌HPV多重感染更多,占37.50%。结论:HPV检测为一种较为方便,创伤小,是一种有效的宫颈病变的筛查方法,对早期发现宫颈癌前病变及宫颈癌具有积极的临床意义。
Objective: To understand the infection of human papillomavirus (HPV) in cervical exfoliative cells of women of childbearing age in Yueqing and to increase the importance of women in early warning and occurrence of related diseases, and to provide a reference for the diagnosis and treatment of cervical lesions. Methods: Female cervical exfoliated cells were scrubbed with a special cervix, and 23 HPV subtypes were detected by gene chip technology. Results: A total of 1013 cases of HPV infection were detected in 3101 cases, the positive rate was 32.67%. The positive rate of cervical intraepithelial neoplasia (CIN) patients was significantly higher than that of cervicitis and condyloma acuminata (P <0.05), but there was no difference between cervicitis and cervical condyloma (P> 0.05). CIN (P <0.05). The genotypes of HPV-positive patients were mainly high-risk type, the first five were HPV16, 52, 58, 18 and 33; the low-risk type was HPV6 and 11. Cervical cancer HPV multiple infection more, accounting for 37.50%. Conclusion: HPV test is a more convenient and less traumatic injury. It is an effective screening method for cervical lesions and has positive clinical significance for the early detection of cervical precancerous lesions and cervical cancer.