论文部分内容阅读
To study the effects ofheparin-coated stent (Wiktor-I) on recovering the balance between endothelin-1(ET-1) and calcitonin gene-related peptide (CGRP) both in the plasma of coronary sinus and peripheral vein after stent implantation. Methods: The patients with coronary artery disease (n=30) were divided into non-coated stent (NCS)group (n=16) andheparin-coated stent (HCS) group (n=14). Circulating ET-1 and CGRP levels were measured by radioimmunoassay (RIA) in the 2 groups at the paired sampling sites, namely the coronary sinus (Cs) and peripheral vein (Pv). The ratio of ET/CGRP was also calculated to reflect the balance of ET and CGRP. Results: In NCS group plasma ET-1 concentrations exhibited 2 peaks at 0 min and 12 h after stent implantation, CGRP levels were highly consistent with that of ET-l, and the ratio of ET/CGRP increased markedly at post-PTCA 5 min, persisting until post-stent 12 h.While in HCS group ET-1 levels and the ratio of ET/CGRP were decreased dramatically compared with that of NCSgroup at 5 min, 10 min and 12 h post-stent (P<0.05, P<0.01 and P<0.05, respectively). There was no remarkable difference of CGRP levels between the 2 groups. Conclusions: Heparin-coated stent can decrease the post-stent circulating ET-1 levels and recover the balance between ET-1 and CGRP.