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根据苏联药物化学专家苏金娜教授的报告,異菸肼在1:16,000,000的稀释度,即能抑制结核桿菌的繁殖。它能直接杀死结核菌,故与其它抗结核药如对氨基水杨酸钠、氨硫脲、链霉素等不同,但它能起抗药性,同时由于它在化学结构上具有游离肼基(—NHNH_2),生理效应很强,小量即能引起某些副作用。针对異菸肼上述缺点,苏联科学家首先合成了一系列異菸肼的衍生物,主要者有下列三种:
According to Prof. Su Jinna, a professor of medicinal chemistry from the Soviet Union, isoniazid inhibits the growth of Mycobacterium tuberculosis at a dilution of 1: 16,000,000. It can directly kill Mycobacterium tuberculosis, it is different from other anti-TB drugs such as sodium paracetamol, thiosemicarbazide, streptomycin, etc., but it can play a resistance, and because it has a chemical structure with free hydrazine groups (-NHNH_2), the physiological effect is strong, a small amount that can cause some side effects. For the above shortcomings of isoniazid, Soviet scientists first synthesized a series of derivatives of isoniazid, the main ones are the following three: