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目的观察视网膜母细胞瘤(RB)中Fas和Fas配体(FasL)的表达特征。方法应用免疫组化法检测32例RB标本中Fas和FasL的表达。结果Fas和FasL在RB中的阳性表达率分别为70.6%和65.8%,二者呈正相关( P <0.001)。分化程度低的和经过放疗的表达率明显增高( P <0.05或0.01)。其表达率与视神经受浸润与否、眼内期或青光眼期无关( P >0.05)。结论RB中Fas及FasL高表达,分化程度越低表达越强。Fas和FasL的表达可作为临床判断RB恶性程度的指标之一。
Objective To investigate the expression of Fas and Fas ligand in retinoblastoma (RB). Methods Immunohistochemistry was used to detect the expression of Fas and FasL in 32 cases of RB specimens. Results The positive rates of Fas and FasL in RB were 70.6% and 65.8% respectively, which were positively correlated with each other (P <0.001). The poorly differentiated and radiotherapy-induced rates were significantly higher (P <0.05 or 0.01). The expression rate and infiltration of the optic nerve or not, intraocular or glaucoma period has nothing to do (P> 0.05). Conclusion The expression of Fas and FasL in RB is high, and the lower the degree of differentiation is, the stronger the expression is. The expression of Fas and FasL can be used as an index to judge the degree of malignancy of RB clinically.