Time course of expression of intermediate filament protein vimentin,nestin and desmin in rat renal g

• 作 者: Eishin Yaoita Yutaka Yoshida Masaaki Nameta Tadashi Yamamoto
• 机 构: Division of Cardiology Department of StructuralPathology,Institute of Nephrology,
• 出 处: Chinese Medical Journal
• 发表日期: 2007年13期
• 关键词: vimentin nestin desmin glomerular cytoskeleton filament insight elucidated Vimen

Podocytes in renal glomerulus express unusualintermediate filament proteins (IFs) for visceralepithelial cells. IFs cytoskeleton is mainly composed ofvimentin, nestin and desmin. Tissue injury is oftenaccompanied by changes in gene expression of IFs.Enhanced desmin staining in podocytes are observed in avariety of rat experimental models of podocyte injuryincluding puromycin aminonucleoside (PAN)nephrosis. It has not been elucidated whetherexpression of vimentin and nestin is up-regulated inpodocyte injury. To further gain insight into expression ofIFs in podocytes, we investigated the time course ofvimentin, nestin and desmin in PAN nephrosis.

Tissue injury is often companied by changes in gene expression of IFs. Enhanced desmin staining in podocytes are observed in avariety of rat experimental. models of podocyte injuryincluding puromycin aminonucleoside (PAN) nephrosis. It has not been elucidated whetherexpression of vimentin and nestin is up-regulated inpodocyte injury. We investigated the time course of vimentin, nestin and desmin in PAN nephrosis.