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大剂量维生素C(以下简称大量维C)治疗急型重症克山病患者的成功,以及亚硒酸钠大面积预防克山病的显效,是60年代在克山病防治工作上两大突破。全国地方病研究者对克山病的病因作了大量有益的探讨。至今已提出“营养”、“水土”、“感染”、“中毒”等病因学说,但对克山病的特异的病因仍未作出最后的定论。为什么大量维C可以治疗急型重症克山病?硒可以预防克山病发生呢?其生化机制是什么?大量维C和硒在治与防问题上有无内在联系?
The success of large doses of vitamin C (hereinafter referred to as a large amount of vitamin C) in the treatment of acute severe Keshan disease and the remarkable effectiveness of sodium selenite in preventing Keshan’s disease are the two major breakthroughs in prevention and treatment of Keshan disease in the 1960s. National endemic researchers made a great deal of useful research on the etiology of Keshan disease. Up to now, the etiology of “nutrition”, “soil and water”, “infection” and “poisoning” have been put forward. However, the specific etiology of Keshan disease has not yet reached a final conclusion. Why a large number of Victoria C can treat acute severe Keshan disease? Selenium can prevent Keshan disease occurs? What is the biochemical mechanism? A large number of Victoria C and selenium in the governance and prevention of the problem there is no intrinsic link?