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过去对于谷胱甘肽代谢的研究,大多是用雄鼠进行的,故鼠肝谷胱甘肽水平的调节机制是否存在性别差异,未见文献报道.本文作者采用7和12周龄的雄鼠和雌鼠(Sprague-Dawley种)进行实验,分别测定了鼠肝谷胱甘肽水平和相关的酶活性,以研究它们在性别和年龄上的差异.实验发现,12周龄雄鼠肝细胞内还原型谷胱甘肽(GSH)水平较高,7周龄雄鼠和雌鼠的GSH水平无明显差别:7和12周龄雄鼠与同周龄雌鼠的氧化型谷胱甘肽(GSSG)水平几乎相同.7周龄
In the past, glutathione metabolism was mostly studied in male rats, so there is no gender difference in the regulatory mechanism of glutathione level in rat liver.We did not report in the literature.In this study, male and female rats of 7 and 12 weeks old And female rats (Sprague-Dawley species) were tested, respectively, the level of glutathione in rat liver and related enzyme activity, in order to study their differences in gender and age.Experiments found that 12 weeks old male rat hepatocytes There was no significant difference in GSH levels between male and female 7-week-old male and female mice at 7 and 12 weeks of age with oxidized glutathione (GSSG ) Are almost the same level .7 weeks old