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B因子是补体旁路的重要成分,参与机体的防御,在炎症过程,细胞和组织损伤中起重要作用。它的检测除可用特异性抗B因子血清作免疫扩散加以定量外,还有溶血法,它是利用兔红细胞(以下简称RE)可以使B因子活化,激活补体旁路,导致RE溶解的特点。将正常人新鲜血清加热去除其中B因子(以下简称RB),由于这种血清中缺少B因子,使旁路不会依次被激活,因此当加入RE后并不发生溶血。只有当加入含B因子的待检血清后,使旁路的连锁反应又重新完成,即可发生溶血,溶血的程度与待检血清中B因
Factor B is an important component of complement bypasses and participates in the body’s defense and plays an important role in inflammatory processes, cell and tissue damage. Its detection can be quantified by using specific anti-B factor serum for immune diffusion, as well as hemolytic method. It uses rabbit erythrocytes (hereinafter referred to as RE) to activate factor B, activate complement bypass, and cause RE to dissolve. Heating normal fresh serum to remove B factor (hereinafter referred to as RB), due to the lack of B factor in this serum, the bypass will not be activated in turn, so when added RE does not occur after hemolysis. Only when adding serum containing B factor to be seized, the bypass chain reaction was re-completed, the hemolysis can occur, the degree of hemolysis and to be seized serum B