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目的 探讨胰岛素诱导基因2(INSIG2) rs7566605多态性与学龄儿童肥胖及胰岛素抵抗等的相关性.方法 采用随机整群抽样法,在山东省济南市抽取了642名7～12岁学龄儿童为研究对象进行.体格检查和代谢指标测定,对INSIG2rs7 566605进行基因分型:野生纯合型(GG)、突变杂合型(GC)及突变纯合型(CC).采用加性模型、显性模型、隐性模型及超显性模型等探讨rs7566605与肥胖的关系.并探讨不同基因型间胰岛素抵抗和脂质代谢等指标的差异.结果 (1)调整性别、年龄后,rs7566605GC杂合型比GG/CC纯合型超重肥胖的危险性高(OR=1.487；95％CI=1.069-2.067；P=0.018).男性GC杂合型比GG/CC纯合型超重肥胖的危险性高(OR=2.018；95％CI=1.249-3.263；P=0.004),而女性不同基因型间超重肥胖率无显著统计学差异.(2)男性GC杂合型的体重(P=0.031)、腰围(P=0.021)、BMI(P=0.023)、体脂量(P=0.015)、空腹胰岛素(P=0.013)、胰岛素抵抗(P=0.030)均高于GG/CC纯合型,差异有显著的统计学意义.结论 ISNIG2基因rs7566605GC型可能是男性儿童肥胖和胰岛素抵抗的危险因素.“,”Objective To test the association between insulin induced gene 2 (INSIG2) rs7566605 polymorphism and obesity and insulin resistance in Chinese school children.Methods Cluster random sampling was applied and 642 children aged 7 to 12 years were obtained in Jinan,Shandong.Physical examination,biochemical measurements were taken,and rs7566605 was genotyped.Additive,recessive,dominant and overdominant models were applied to explore the relationship between rs7566605 and obesity.Insulin resistance index and lipid related biochemical measurements were compared between genotypes.Results (1)Adjusted by gender and age,GC carriers were more likely to be overweight and obese than GG/GC carriers (OR=1.487; 95％CI=1.069-2.067; P=0.018).In boys,GC carriers were more likely to be overweight and obese than GG/GC carriers (OR=2.018; 95％CI=1.249-3.263; P=0.004).Girls did not have any trend to be obese in any genotype.(2) In boys,weight (P=0.031),waist (P=0.021),BMI (P=0.023),body fat (P=0.015),insulin (P=0.013) and HOMA-IR (P=0.030)were more or higher in GC carriers than those in GG/CC.Conclusion INSIG2 rs7566605 GC could be a risk factor for obese and insulin resistance in boys.