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1992年4月～1994年12月,对广西南宁、桂林等6个市县城乡地区自然人群2086人进行戊型肝炎感染流行状况调查研究。用ELISA法检测血清抗 -HEV -IgG。结果表明自然人群中有较高的HEV感染,抗 -HEV标化阳性率为20.2 %。各地区的HEV感染率有较大的差别,从8.6 %至47.0%,以桂西北山区壮族聚集的凌云县最高(47.0 %) ,南宁市最低(8.6 %)。城市人群HEV感染率(16.0 %)低于农村(21.8 %)(P<0.01)。HEV感染率随年龄增长而上升,生命早期即有高度的HEV感染,1～4岁为7.2 %,5～9岁开始上升(9.0 %),10岁以后感染率成倍增加(14.8 %～29.7 %) ,有两个小峰分别在30～39岁(29.3 %)和50岁以上(33.3 %)。HEV感染率高峰年龄较国内外提前10年 ,男女性总抗 -HEV阳性率无明显差别(分别为18.8 %和21.2 %),但10～39岁女性抗HEV阳性率(26.2 %)高于男性(19.8 %),P<0.01,说明人群对HEV普遍易感。结果表明广西为我国戊型肝炎高感染区 ,对导致广西地区高HEV流行率的有关流行因素进行了讨论。
From April 1992 to December 1994, 2,086 people in natural populations in urban and rural areas of 6 cities and counties in Guangxi including Nanning and Guilin were investigated for prevalence of hepatitis E infection. Serum anti-HEV-IgG was detected by ELISA. The results showed that the natural population has a higher HEV infection, anti-HEV standard positive rate was 20.2%. The prevalence of HEV infection varies greatly from 8.6% to 47.0% in all regions, with the highest in Lingyun County (47.0%) and the lowest in Nanning City (8.6%) in the mountainous areas of Guangxi Zhuang Autonomous Region. The prevalence of HEV in urban population (16.0%) was lower than that in rural areas (21.8%) (P <0.01). The prevalence of HEV increased with age, with a high prevalence of HEV infection in early life, ranging from 7.2% at 1 to 4 years of age to 9.0% at 5 to 9 years of age and from 14.8% to 29.7 at 10 years of age %), With two small peaks at 30-39 years (29.3%) and over 50 years (33.3%), respectively. The peak age of HEV infection was 10 years earlier than that at home and abroad. There was no significant difference in the total positive rate of anti-HEV between men and women (18.8% and 21.2% respectively), but the positive rate of HEV in women aged 10-39 (26.2%) was higher than that of men (19.8%), P <0.01, indicating that the population is generally susceptible to HEV. The results show that Guangxi is a high-incidence area of hepatitis E in China, and the prevalence of high prevalence of HEV in Guangxi is discussed.