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储脂细胞为位于肝窦周围的肝脏非实质细胞之一,其主要生理功能为储存维生素A,在肝纤维化形成过程中,为产生细胞外基质的主要细胞群,近年来研究发现,该细胞具有收缩性,能调节肝窦血流。体外培养及体内研究发现,储脂细胞的收缩性受内皮素及一氧化氮等多种血管活性物质的调节。激活的储脂细胞与血管活性物质的相互作用可能是肝硬变时产生门静脉高压的重要病理机制之一。对储脂细胞的收缩性进行调节有可能成为降低门静脉高压的新途径。
The fat-storing cells are one of the liver non-parenchymal cells located around the hepatic sinusoid. The main physiological function of the fat-storing cells is the storage of vitamin A. In the process of hepatic fibrosis, it is the main cell group that produces the extracellular matrix. In recent years, it has been found that the cells With contractility, can regulate hepatic sinus blood flow. In vitro culture and in vivo studies have shown that the contractility of lipid-storing cells is regulated by a number of vasoactive substances, such as endothelin and nitric oxide. The interaction between activated fat-storing cells and vasoactive substances may be one of the important pathological mechanisms of portal hypertension in liver cirrhosis. Regulating the contractility of the fat-storing cells may be a new way to reduce portal hypertension.