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贲门炎症是否说明存在胃食管反流性疾病(GERD)或仅是幽门螺杆菌(Hp)感染所致全胃炎的一种表现,目前尚不明确。研究旨在探讨有或无GERD患者中Hp感染、酸反流性疾病在贲门炎和贲门肠化生发生中所起的作用。 病人和方法:选择1995年9月至1997年1月接受内镜检查的患者共85例。剔除在内镜检查前30天内使用过抗生素,有胃、食管手术史,既往或现在有消化不良、消化性溃疡、胃癌及已知有Hp感染者。GERD诊断依据为1周内至少有2次以上的烧心感和(或)反酸,并持续至少6个月以上,无Barrett食管或食管肿瘤。
Whether or not cardia inflammation indicates the presence of gastroesophageal reflux disease (GERD) or is only a manifestation of total gastritis caused by Helicobacter pylori (Hp) infection is unclear. The aim of this study was to investigate the role of Hp infection and acid reflux disease in the development of cardia and cardiac intestinal metaplasia in patients with and without GERD. Patients and Methods: A total of 85 patients undergoing endoscopy between September 1995 and January 1997 were selected. Excluding the use of antibiotics within 30 days prior to endoscopy, history of gastric and esophageal surgery, previous or current indigestion, peptic ulcer, gastric cancer, and those known to have Hp infection. GERD is based on a diagnosis of heartburn and / or acid reflux for at least 2 times in 1 week and for at least 6 months without Barrett’s esophagus or esophageal neoplasm.