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药物引起的溶血性贫血归类于“免疫性”贫血。因药物在血清中与大分子蛋白结合成抗原,形成抗原一抗体复合物,这种复合物附着于红细胞膜上(机理不清),既可在补体参与下或者与活性 C_3(补体3)结合于红细胞表面,使红细胞受到破坏,继则由巨噬细胞识别,并在网状内皮系统进一步破坏。有些药物没有补体结合也可引起溶血作用,此时,红细胞表面可能附有免疫球蛋白。作者报告一例男性、67岁,反复血红蛋白尿患者。于1966年8月,口服降压药(甲
Drug-induced hemolytic anemia is classified as “immune” anemia. Because the drug binds to the macromolecule protein in the serum and forms an antigen-antibody complex, the complex adheres to the membrane of the erythrocyte (unclear mechanism), and can be either involved in complement or bound to active C_3 (complement 3) On the surface of erythrocytes, erythrocytes are destroyed, followed by macrophages and further destruction in the reticuloendothelial system. Some drugs can also cause hemolysis without complement fixation, this time, the surface of red blood cells may be attached to immunoglobulin. The authors report a male, 67 years old, with recurrent hemoglobinuria. In August 1966, oral antihypertensive drugs (A