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目的 评价复方溶石剂 1号的溶石效果和毒性作用。方法 体外溶石效果实验和 2 0只兔胆囊注射溶石剂后各时间段的血液生化指标变化及各脏器的病理改变。结果 复方溶石剂 1号对 50 0mg的胆固醇结石溶解时间少于 2 5min( 2 1± 4 9min) ,对动物的血液生化指标影响不大 ,除胆囊外未对全身其他脏器造成损害。结论 复方溶石剂 1号是一种新型、安全、高效、低毒的胆固醇结石直接溶石剂
Objective To evaluate the effect of dissolving stone and toxicity of Compound Limestone No.1. Methods In vitro dissolution experiment and blood biochemical parameters of 20 rabbits gallbladder injection of limestone after each time period and the pathological changes of various organs. Results The dissolving time of compound calculi 1 on 50 0 mg cholesterol stones was less than 25 min (21 ± 4 9 min), which had little effect on the blood biochemical parameters of animals and did not cause damage to other organs except the gallbladder. Conclusion Compound Limestone No.1 is a new type of safe, efficient and low toxic direct stone dissolving agent for cholesterol