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目的研究采用不同剂量复方甲亢片治疗亚临床甲状腺功能亢进症(甲亢)患者,对其临床疗效的影响。方法 150例亚临床甲亢患者,按照复方甲亢片药物用量不同将其分为A组(高剂量组)、B组(中剂量组)、C组(低剂量组),各50例。患者均治疗3个月后观察其血清值变化。结果 A、B、C三组入院时血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)比较,差异无统计学意义(P>0.05);经治疗后A、B、C三组FT3、FT4比较,差异无统计学意义(P>0.05);治疗后A、B组TSH高于C组,且恢复至正常水平,差异有统计学意义(P<0.05)。结论采用高剂量及中等剂量的复方甲亢片对于亚临床甲亢患者的治疗效果较好,但临床具体制定治疗方案时需注意结合患者自身病情发展及医生诊断而准确判断用药量。
Objective To study the effect of different doses of compound hyperthyroidism tablets on patients with subclinical hyperthyroidism (hyperthyroidism) and its clinical effect. Methods A total of 150 patients with subclinical hyperthyroidism were divided into group A (high dose group), group B (medium dose group), group C (low dose group), and 50 patients in each group according to the dosage of compound. Patients were treated for 3 months after the observed changes in serum values. Results There was no significant difference in serum free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropin (TSH) between the three groups at admission (P> 0.05) There were no significant differences in FT3 and FT4 between groups A, B and C (P> 0.05). After treatment, the TSH in groups A and B were higher than those in group C, and returned to normal levels (P < 0.05). Conclusion High-dose and medium-dose compound Kethylaxis tablets are effective in treating patients with subclinical hyperthyroidism. However, when formulating treatment programs clinically, attention should be paid to accurately determine dosage based on the patient’s own condition and doctor’s diagnosis.