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目的探讨血清游离前列腺特异性抗原(fPSA)、血清总前列腺特异性抗原(tPSA)以及f/tPSA比值在前列腺癌确定诊断中的价值。方法选取2013年1月—2016年12月共701例该院行前列腺系统性穿刺活检或经尿道前列腺电切术患者的血清fPSA、tPSA并计算f/tPSA。结果前列腺癌组患者的fPSA、tPSA明显高于前列腺增生组(P<0.05),而f/tPSA低于前列腺增生组(P<0.05)。当tPSA在4~10ng/ml范围之内时,前列腺癌组与前列腺增生组患者的tPSA的差异均无统计学意义(P>0.05),但f/tPSA差异有统计学意义(P<0.05),前列腺癌组明显低于前列腺增生组。结论联合检测血清fPSA、tPSA以及f/tPSA比值明显优于单纯检测tPSA,在前列腺癌的诊断中具有重要的价值。
Objective To investigate the value of serum free prostate-specific antigen (fPSA), serum total prostate-specific antigen (tPSA) and f / tPSA ratio in the diagnosis of prostate cancer. Methods From January 2013 to December 2016 a total of 701 cases of the hospital underwent systematic prostate biopsy or transurethral resection of prostate in patients with serum fPSA, tPSA and calculated f / tPSA. Results The fPSA and tPSA levels in patients with prostate cancer were significantly higher than those in benign prostatic hyperplasia (P <0.05), while those in benign prostatic hyperplasia (P <0.05). There was no significant difference in tPSA between the prostate cancer group and benign prostatic hyperplasia group when tPSA was in the range of 4 ~ 10ng / ml (P> 0.05), but the difference of f / tPSA was statistically significant (P <0.05) , Prostate cancer group was significantly lower than benign prostatic hyperplasia group. Conclusion The combined detection of serum fPSA, tPSA and f / tPSA ratio is superior to the simple detection of tPSA, which is of great value in the diagnosis of prostate cancer.