论文部分内容阅读
目的:回顾性分析宁夏回族自治区794例回、汉族食管癌手术患者临床生物学特征及预后对比分析.方法:选择2003-01-01/2012-12-31在宁夏医科大学总院住院治疗的794例回、汉族食管癌手术患者为研究对象,所有患者均经胃镜和病理证实,其中回族117例(14.7%),汉族677例(85.3%).收集整理包括年龄、性别、职业、血型、家族史、烟酒嗜好、病理分化、肿瘤长度、肿瘤部位、病理类型及TNM分期等指标,输入Excel表格,建立数据库.采用SPSS18.0统计软件对各项指标进行统计学分析,计数资料均采用χ~2检验,生存分析采用Kaplan-Meier法.结果:794例回、汉族食管癌患者在年龄构成上均以老年(≥60岁)为主(54.7%vs61.4%),两民族间分布差异无统计学意义(χ~2=3.100,P=0.212);回、汉族食管癌手术患者的性别构成均以男性为主(74.4%vs77.4%),两民族间分布差异无统计学意义(χ~2=0.520,P=0.471);回、汉族食管癌患者在职业构成上均以农民为主(51.3%vs 38.7%),两民族间分布差异无统计学意义(χ~2=7.094,P=0.069);回、汉族食管癌患者在吸烟、饮酒方面,两民族间分布差异有统计学意义(χ~2=31.089,P<0.0001;χ~2=30.647,P<0.0001);回、汉族食管癌患者在家族史、ABO血型分布构成上皆无统计学意义(χ~2=0.707,P=0.400;χ~2=4.706,P=0.319);回、汉族食管癌患者肿瘤长度和TNM分期在两民族间分布差异无统计学意义(χ~2=0.450,P=0.799,χ~2=5.201,P=0.392);回、汉族食管癌患者的病理类型均以鳞癌为主(86.3%vs 89.2%),两民族间分布差异无统计学意义(χ~2=1.534,P=0.674);回、汉族食管癌患者肿瘤位置均以胸中段为主(63.3%vs 53.6%),两民族间分布差异无统计学意义(χ~2=1.878,P=0.598);回、汉族食管癌手术患者间分化程度皆以中低分化为主(74.4%vs 81.6%),两民族间分布差异无统计学意义(χ~2=3.632,P=0.304).回、汉族患者中位生存时间分别为29 mo和38 mo,两民族间生存时间差别无统计学意义(χ~2=0.655,P=0.418).结论:宁夏回、汉族食管癌手术患者在大部分临床生物学特征及预后等因素方面均无明显差异.两个民族食管癌手术患者均多见于中老年男性,病理类型以鳞癌多见,分化程度以中低分化为主,预后及生存差.
Objective: To retrospectively analyze the clinical biological characteristics and prognosis of 794 cases of esophageal cancer patients in Ningxia Hui Autonomous Region and retrospective analysis.Methods: A total of 794 hospitalized patients in Ningxia Hui Autonomous Region General Hospital from January 2003 to January 2012 were enrolled in this study. Cases of esophageal cancer patients were enrolled in this study. All patients were confirmed by gastroscopy and pathology, of which 117 (14.7%) were Hui people and 677 (85.3%) Han people were collected, including age, sex, occupation, blood type, History, smoking and drinking habits, pathological differentiation, tumor length, tumor location, pathological type and TNM staging and other indicators, enter the Excel form, the establishment of the database.Statistical analysis of the indicators using SPSS18.0 statistical software, count data were used χ ~ 2 test and Kaplan-Meier method.Results: The age distribution of 794 cases of esophageal cancer in Han nationality was mainly in the elderly (≥60 years old) (54.7% vs61.4%), and there was a significant difference between the two ethnic groups There was no significant difference between the two ethnic groups (χ ~ 2 = 3.100, P = 0.212). The sex composition of the patients in both esophageal and gynecological surgeries was male (74.4% vs77.4%). There was no significant difference between the two ethnic groups χ ~ 2 = 0.520, P = 0.471); back, Han esophageal cancer patients (51.3% vs 38.7%). There was no significant difference between the two ethnic groups (χ ~ 2 = 7.094, P = 0.069). In terms of smoking and alcohol consumption, There was significant difference between the two ethnic groups (χ ~ 2 = 31.089, P <0.0001; χ ~ 2 = 30.647, P <0.0001). There was no statistical significance in the family history and ABO blood group distribution between Hui and Han nationality esophageal cancer patients (Χ ~ 2 = 0.707, P = 0.400; χ ~ 2 = 4.706, P = 0.319). There was no significant difference in the tumor length and TNM stage between the two ethnic groups in the Hui and Han nationality esophageal cancer patients (χ ~ 2 = 0.450 , P = 0.799, χ ~ 2 = 5.201, P = 0.392). The pathological types of both esophageal cancer patients were mainly squamous cell carcinoma (86.3% vs 89.2%), with no significant difference between the two ethnic groups ~ 2 = 1.534, P = 0.674). The tumor location in the patients with esophageal cancer was mainly in the mid-thoracic segment (63.3% vs 53.6%) in the two groups. There was no significant difference in the distribution between the two ethnic groups (χ ~ 2 = 0.598). There was no significant difference in the degree of differentiation between the two groups (χ ~ 2 = 3.632, P = 0.304) in the patients with both esophageal cancer and esophageal cancer (74.4% vs 81.6%). , Han Chinese patients with median survival were 29 mo and 38 mo, there was no significant difference in survival time between the two ethnic groups (χ ~ 2 = 0.655, P = 0.418) .Conclusion: There is no significant difference in most clinical biological characteristics and prognosis between Hui and Han patients with esophageal cancer Both ethnic esophageal cancer patients are more common in middle-aged and elderly men, the pathological type of squamous cell carcinoma more common, the degree of differentiation in the poorly differentiated, prognosis and poor survival.