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Ehrlich(1891年)首先描述在周围血中发现红细胞碎片,认为是贫血时血液中某些化学成分所造成。以后不少人观察,发现在某些溶血性贫血,血栓性血小板减少性紫癜、广泛转移癌、恶性高血压、子痫、结节性动脉周围炎、急慢性肾功能衰竭等病患者的血液中,也可出现红细胞碎片及变形红细胞。由于当时对病因不清楚,故命名很不统一。1952年Symmer对血栓性血小板减少性紫癜首次称之为血栓性微血管性溶血性贫血,但他没有说明本病溶血与血管病变的关系。1962年Brain等人对上述病患者
Ehrlich (1891) first described the discovery of red blood cell debris in the peripheral blood, which is believed to be caused by certain chemical components of the blood during anemia. After a lot of people observed and found in some hemolytic anemia, thrombotic thrombocytopenic purpura, extensive metastatic cancer, malignant hypertension, eclampsia, nodular periarteritis, acute and chronic renal failure and other diseases in the blood , But also red blood cell debris and deformed red blood cells. Because at that time the cause is not clear, so the name is not uniform. Symmer in 1952 thrombotic thrombocytopenic purpura was first called thrombotic microvascular hemolytic anemia, but he did not explain the disease hemolysis and vascular disease. 1962 Brain et al on the above patients