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规范化的肝细胞癌（HCC）筛查是实现早期诊断的重要环节。国内外HCC诊疗指南均推荐对于高危人群定期使用常规超声进行筛查，对于筛查阳性的人群应进一步选择动态增强影像技术进行无创性诊断，主要包括超声增强造影、动态增强计算机断层扫描、动态增强磁共振成像（MRI）和肝胆特异性对比剂Gd-EOB-DTPA增强MRI（EOB-MRI）。在临床实践中，应准确界定高危人群，进行个体化风险分层，不断完善肝癌早期筛查的标准和诊断流程，使患者最大化获益。“,”Standardized hepatocellular carcinoma (HCC) screening is very important for early diagnosis. Chinese and international HCC clinical guidelines recommend regular ultrasound screening for high-risk patients. Noninvasive dynamic enhanced imaging technology should be selected for the positive screenin population to get the further diagnosis, including contrast-enhanced ultrasound (CEUS), dynamic contrast-enhanced CT, dynamic contrast-enhanced MRI and Gd-EOB-DTPA enhanced MRI (EOB MRI). In clinical practice, early diagnose of HCC relies on accurate identification and stratification of high-risk patients, and systematic approach based on dynamic contrast-enhanced imaging.